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Pulsatile pump for in vitro patient specific cardiovascular flow experiments

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Project Overview

The multidirectional nature of flow within the cardiovascular system makes the comprehensive non-invasive characterization and quantification of normal and pathological blood flow difficult and challenging. Standard imaging techniques such as Doppler ultrasound or magnetic resonance imaging (MRI) are still limited in their ability to fully characterize this complex flow. 4D Flow MRI, with its ability to assess multidirectional volumetric flow, offers the opportunity to non-invasively assess the performance and efficiency of the cardiovascular system, both in vivo in patients and in vitro using patient-specific models. Currently we use data acquired from in vivo MRI evaluations to create patient-specific in vitro models using additive manufacturing techniques. Physical models are subjected to different inflow and resistance conditions during MRI in vitro experiments using a bypass non-pulsatile perfusion pump. The goal of this project is to design a system that in series with the perfusion pump can convert the continuous flow in pulsatile flow that reproduces patient-specific flow waves as inputs for the in vitro model.

Team Picture

Jaime Mortier, Adam Strebel, Shaun Pomerenke, Maria Maza
Jaime Mortier, Adam Strebel, Shaun Pomerenke, Maria Maza

Images

Prototype
Prototype
TCPC MRI Scan
TCPC MRI Scan
MRI Scanner
MRI Scanner
Flexible TCPC model
Flexible TCPC model
In vitro 4D flow results
In vitro 4D flow results

Contact Information

Team Members

  • Adam Strebel - Team Leader
  • Jaime Mortier - Communicator & BPAG
  • Shaun Pomerenke - BSAC & BWIG

Advisor and Client

  • Mitchell Tyler - Advisor
  • Dr. Alejandro Roldan - Client

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