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Microfluidic device to study biofilm infection on a vascular catheter

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Project Overview

The goal of the project is to develop a microfluidic device that mimics a vascular catheter infection in a patient and can be used for microscopy experiments examining the immune response. The device would have an outer endothelial layer and an inner catheter. The areas would have an interface at the tip of the catheter. The lumen of the catheter would be able to be inoculated to produce a biofilm. Some of the future applications for this device may include examining how neutrophils migrate to biofilms in the presence and absence of an endothelial cell lining, comparing immune recognition of biofilm and free floating cells, measuring the cytokine responses, and examining the impact of disrupting genetic pathways in either the microorganism or immune cells.

Team Picture

Team members from left to right: Stephanie O'Leary, Jacob Hindt, Steve Wang, Amy Kim
Team members from left to right: Stephanie O'Leary, Jacob Hindt, Steve Wang, Amy Kim

Contact Information

Team Members

  • Jacob Hindt - Team Leader
  • Stephanie O'Leary - Communicator
  • Xiyu Wang - BSAC & BPAG
  • Amy Kim - BWIG

Advisor and Client

  • Prof. Tracy Jane Puccinelli - Advisor
  • Dr. Jeniel Nett - Client

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