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Microfluidic sensing chip: Microfluidic device for long-term maintenance of biosensing cells

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Creation of a microfluidic chip for the long-term housing of bio-sensing yeast cells in order to detect human endocrine disruptors.

Project Overview

This project will design a microfluidic device for maintaining yeast cells at constant density and in a single plane (i.e. monolayer). These yeast cells contain sensing proteins that allow them to detect human endocrine disruptors (HEDCs) and express fluorescent proteins in response to the presence of these HEDCs. The device must allow for replenishing these yeast biosensors with appropriate nutrients and delivering samples to be tested for HEDCs to the yeast. Any yeast growth within the device must be handled so that the yeast stay at a constant density and number. Finally, an ideal device would contain multiple compartments for yeast with different HEDCs sensors.

Team Picture

From Left to Right: Ian Peterson, Amy Cao, Jiahe Jin, Ben Walker
From Left to Right: Ian Peterson, Amy Cao, Jiahe Jin, Ben Walker

Contact Information

Team Members

  • Amy Cao - Team Leader
  • Ian Petersen - Communicator & BSAC
  • Benjamin Walker - BWIG
  • Jiahe Jin - BPAG

Advisor and Client

  • Prof. Paul Campagnola - Advisor
  • Prof. Megan McClean - Client
  • Prof. Bhuvana Krishnaswamy - Alternate Contact

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