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Microfluidic device for organoids

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Develop an under-oil microfluidic chip capable of housing organoids and receiving CAP Jet treatement.

Project Overview

Current strategies for preclinical studies on disease models and novel therapies have relied on monolayers of cells in well plates and animal models. These models do not emulate the in vivo environment of the human body and thus usually are not medically applicable: monolayers lack the 3D extracellular matrix, circulatory system, and complexities of the human body, and animal models have vastly different physiologies and immune systems as compared to humans [1]. The lack of similarity between the typical cell culture's environment and the physiology of the human body does not allow for clinically relevant testing of possible treatments for diseases such as cancer. Growing cells in a circulatory system with a 3D tissue structure would support physiologically relevant cell growth and more accurately represent the microenvironment of cells in vivo. The goal of this project is to develop a microfluidic device that supports the growth of organoids, 3D masses composed of multiple cell types, and emulates the microenvironment of the human body. The specific clinical and translational treatment that this device is being designed for is the exposure of the media to cold atmospheric plasma (CAP). Thus, the device will allow for controlled delivery of treatments to the cells in culture, but also adaptable to other translational therapies.

Team Picture

Picture of the BME design team for microfluidic device for organoids
Picture of the BME design team for microfluidic device for organoids

Contact Information

Team Members

  • William Dunn V - Team Leader
  • Mackenzie Beam - Communicator
  • Sandhya Nagarajan - BSAC
  • Navjot Rehal - BWIG & BPAG

Advisor and Client

  • Prof. Paul Campagnola - Advisor
  • Hau Le - Client

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